"Children with OCD are being treated with CBT before being re-evaluated and re-scanned in the MRI—a wonderful treatment opportunity for children in need at no cost. The goal of the study is to identify alterations in control circuits that improve with the remission of OC symptoms, and also to determine if those alterations are present in children with subclinical symptoms. If so, this study will pave the way for a clinical trial aimed at early targeting of those circuits (with, for example, cognitive control training) for the prevention of this disabling illness in children."
"With recent technological advances, Marsh and her colleagues are doing what their counterparts in other branches of medicine have been doing for more than a century: putting OCD under the microscope in the search for its biomarkers, the concrete signs of mental disorders that could revolutionize how they get diagnosed, treated and perhaps even prevented."
Rachel Marsh, PhD, reassures the readers that "the Research Domain Criteria Project (RDoC) has been launched by NIMH with the intention of understanding mental illness and dysfunction based on dimensions of observable behavior and neurobiological measures. RDoC is meant to eventually help rewrite the DSM, not abolish it. "
Rachel Marsh, PhD, "has demonstrated in two studies of adults and adolescents with bulimia nervosa (BN) that dysfunction in regions of the brain dedicated to self-regulation, and supported by networks called frontostriatal circuits, may be implicated in the inability to thwart the urge to binge eat and purge."
"Rachel Marsh, PhD, and colleagues at Columbia University and the New York State Psychiatric Institute compared the results of the Simon Spatial Incompatibility task in 40 women (20 with and 20 without BN) who were undergoing functional MRI. . . . The authors concluded that self-regulation in women with BN is impaired because they cannot appropriately engage frontostriatal circuits."
"Women with bulimia nervosa appear to respond more impulsively during psychological testing than those without eating disorders, and brain scans show differences in areas responsible for regulating behavior . . ."